New research from Austria has highlighted the potential benefits that the ketogenic diet can offer to children with Dravet syndrome, a serious form of epilepsy.
Conducted at the Medical University Vienna, the study aimed to evaluate both the effectiveness and tolerability of the high-fat, low-carb diet in comparison with various AEDs among 32 children who had been treated at the centre since 1999.
Overall response to the ketogenic diet was 70 per cent at three months and 60 per cent at 12 months, with no instances of status epilepticus occurring while patients were on the diet, with the frequencies of prolonged generalised and myoclonic seizures also reduced.
Moreover, the diet was not significantly inferior to the current gold standard AED triple combination of stiripentol, valproate and clobazam, as well as bromides, valproate alone, topiramate and vagus nerve stimulation. It was significantly more effective than levetiracetam.
The researchers concluded: 'These data suggest that the ketogenic diet ranks among currently used AEDs as an effective treatment for seizures in Dravet syndrome ... the ketogenic diet should be considered as an early treatment option.'
Dravet syndrome is a rare and extremely damaging form of intractable epilepsy that begins in infancy. It is associated with intense seizures, a high mortality risk and various related conditions.
Posted by Bob Jones
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